In May 2011, Edelstein announced that she would not return for the eighth and final season of House.

She guest-starred in Scandal in 2013, and later three episodes of the ABC series Castle.

, Without a Trace, and Judging Amy, as well as small parts in the films What Women Want, Keeping the Faith, As Good as It Gets, and Daddy Day Care.

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, Superman: The Animated Series (as Mercy Graves, Lex Luthor's bodyguard, a role she later reprised in several episodes of Justice League), Legend of Korra (as Kya, Tenzin's sister) and the video game adaptation of Blade Runner (1997).

Edelstein is a passionate supporter of Best Friends Animal Society, of which she is an Ambassador.

In fact, Common Ground recently bestowed her with an honor on behalf of her efforts to further awareness.

Edelstein currently resides in Los Angeles in a century old home with her family and rescue dogs.

Lisa Cuddy, the Dean of Medicine at Princeton-Plainsboro Teaching Hospital and frequent adversary, friend, and eventual girlfriend of title character Gregory House (Hugh Laurie) on Fox's TV series House.

Edelstein has often spoken fondly of her experiences on the show and fellow cast and crew, especially her friendship and strong working relationship with colleague Hugh Laurie.

On Sports Night, she played a sports reporter who claimed to be a former lover of Josh Charles's character whom he did not remember.

On Seinfeld, she played George Costanza's frustrated girlfriend, the "Risotto Girl" (the only girlfriend of George's to appear in multiple episodes other than Susan Ross).

Bigger roles in TV dramas soon followed, among them the lesbian sister on ABC's Relativity (1996); a high-priced call girl turned Rob Lowe's date on The West Wing (1999); an assigned male at birth (AMAB) transgender woman on Ally Mc Beal (2000); and Ben Covington's (Scott Speedman) girlfriend on Felicity (2001).

She also continued to land guest-star spots on such shows as ER, Frasier, Just Shoot Me!

Edelstein also plans to direct an episode of Season 5. Lisa Cuddy on the hit medical drama which premiered at Sundance and has since been acquired by Lionsgate/Hulu.