Archive footage of Speedman from the previous Underworld films was used in the 2012-&-2016 sequels, Underworld: Awakening and Underworld: Blood Wars; his facial likeness was superimposed on a stand-in for his character's brief role in the film. Speedman last starred as XO Sam Kendal in the ABC military drama series Last Resort, which premiered on September 27, 2012.

Later in 2003, Speedman starred opposite Kate Beckinsale in the supernatural thriller Underworld.

Making an impression on audiences in the stylized vampire-werewolf film, Speedman was honored with a Saturn Award in the category "Cinescape Face of the Future Award".

In July 2009, it was reported that Speedman was to star alongside Dustin Hoffman among others in the film adaption of Barney's Version.

Pre-production began in August 2009, and filming took place in Rome, New York and Canada.

He appeared alongside Willem Dafoe in Anamorph and Wes Bentley in Weirdsville.

Speedman appeared with Liv Tyler in the 2008 horror–thriller The Strangers, and also alongside Rachel Blanchard in Adoration, directed by Atom Egoyan.

Though the appearance earned him an audition, Speedman was not cast in the role, which was ultimately given to Chris O'Donnell.

The audition did, however, give Speedman the exposure he needed and he quickly arranged an agent and began auditioning for Canadian television and film roles.

Speedman's TV debut came in 1995 with the Canadian series Net Worth.